Publications

Below you will find links to the publications of 2016 which describe research financed by the BLUEPRINT project. For the publications of the previous years, please use the links on the left.


 

   Genome Medicine
   November 2016

 
Genome Biology
December 2016
Clinical Epigenetics
December 2016
 
   Making sense of big data
   in health research: towards
   an EU action plan
.
 
Integrating epigenomic data
and 3D genomic structure with
a new measure of chromatin...
Sirtuin functions and
modulation: from chemistry
to the clinic.

 



 
 



 
 
   Nature Rev. Genet
   November 2016

 
Scientific Reports
November 2016
Nature Communications
November 2016
 
   From profiles to function
   in epigenomics.
Changes of bivalent chromatin
coincide with increased
expression of developmental..
.
 
Increased DNA methylation
variability in type 1
diabetes across three.
..
 
 










 
 
   Cell
   November 2016
Cell
November 2016

 
Cell Metabolism
November 2016

 
 
   The International Human
   Epigenome Consortium: a
   Blueprint for scientific
...
 
A cornucopia of advances
in human epigenomics
Glutaminolysis and fumarate
accumulation integrate
immunometabolic and
...
 
 










 
   
   Cell
   November 2016

 
Cell
November 2016

 
Cell
November 2016

 
 
   Genetic drivers of epigenetic
   and transcriptional variation
   in human immune cells

 
Lineage-specific genome
architecture links disease
variants to target genes
Beta-glucan reverses the
epigenetic state of LPS
induced immunological .
..
 










 
     
   Immunity
   November 2016
Cell Stem Cell
November 2016

 
Cell
November 2016

 
 
   Transcriptional landscape
   of human tissue
   lymphocytes unveils
...
 
DNA methylation dynamics
of human hematopoietic
stem cell differentiation

 
The allelic landscape of human
blood cell trait variation and
links to common complex
...
 
 










 
     
   Cell Reports
   November 2016


Cancer Cell
November 2016

Cell Systems
November 2016

 
 
   Distinct trends of DNA
   methylation patterning in
   the innate and adaptive...
 
Decoding the DNA
methylome of mantle cell
lymphoma in the light of...
 
The BLUEPRINT data
analysis portal

 
 









 
     
   Cell Reports
   November 2016
Cell Reports
November 2016
 
Cell Reports
November 2016
 
   eFORGE: a tool for
   identifying cell type-specific
   signal in epigenomic data

 
CD8+ T cells from human
neonates are biased towards
an innate immune response

The hematopoietic
transcription factor RUNX1
and ERG prevent AML1-ETO...
 
 









 
   
   Nature Biotechnology
   September 2016

 
Epigenetics
October 2016
Pediatr. Blood Cancer
October 2016
 
   Co-ChIP enables genome-
   wide mapping fo histone
   mark co-occurrence at ...
Identification and character-
ization of PKF118-310 as
a KDM4A inhibitor
DNA methylation profiling of
pediatric B-cell lymphoblastic
leukemia with KMT2A ...
 
 
 










 
     
   Cell
   Augustus 2016
Cancer Research
August 2016
Science Advances
September 2016

 
 
   The spectrum and regulatory
   landscape of intestinal
   innate lymphoid cells are
...
 
CNS1 somatic mutations in
penile squamous carcinoma
.
Polymyxins and quinazolines
are LSD1/KDM1A inhibitors
with unusual structiral ...
 










 
   









 
 
   Clinical Cancer Research
   June 2016
Science
July 2016
Nucleic Acids Research
July 2016

 
 
   c-Myc modulation &
   acetylation is a key HDAC
   inhibitor target in cancer

 
Early life nutrition modulates
the epigenetic state of
specific rDNA genetic ...
DeepBlue epigenomic data
server: programmatic data
retrieval and analysis of ...
 
 









 
     
   Nature Communications
   June 2016

 
Nature Communications
June 2016
Nature Biotechnology
June 2016
 
   Chromatin accessibility maps
   of chronic lymphocytic
   leukaemia identify subtype..
.
Information recovery from low
coverage whole-genome
bisulfite sequencing
Saturation analysis for whole-
genome bisulfite sequencing
dat
a
 
 
     









 
   Nucleic Acids Research
   May 2016

 
Blood
June 2016

 
Nature Biotechnology
June 2016

 
 
   Dynamic recruitment of Ets1
   to both nucleosome-occupied
   and - depleted enhancer ..
.
 
A high-throughput sequencing
test for diagnosing inherited
bleeding, thrombotic, ...
.
 
Quantitative comparison of
DNA methylation assays for
biomarker development and .
..
 
 










 










 
 
   Epigenetics Chromatin
   March 2016

Nature Commun.
April 2016
Genome Biology
April 2016
 
   Tissue-independent and
   tissue-specific patterns of
   DNA methylation ...


Large-scale production of
megakaryocytes from
human pluripotent stem ...

Single-cell epigenomics:
powerful new methods for
understanding gene ...
 
 


 
 




 
   
   Oncotarget
   March 2016

Nature Genetics
March 2016
PloS Genetics
March 2016
 
   Histone acetyltransferase
   inihibitor CPTH6 preferentially
   targets lung cancer...
DNA methyaltion dynamics
during B cell maturation
underlie a continuum of ...
Quantitative trait loci identify
functional noncoding vairation
in cancer.

 
 










 
     
   J Med Chem
   February 2016

Scientific Reports
February 2016

 
Bioinformatics
February 2016

 
 
   1,4-dihydropyridines active
   on the SIRT1/AMPK pathway
   ameliorate skin repair...

Significant impact of miRNA-
target gene networks on
genetics of human complex..

LOLA: enrichment analysis
for geneomics region sets and
regulatory elements in ...

 
     










 
   Cell Reports
   February 2016

Biochem Pharmacol
February 2016
J Med Chem
February 2016
 
   Epigenomic co-localitation
   and co-evolution reveal a key
   role for 5hmC as a ...

 
The histone acetyltransferase
p300 inhibitor C646 reduces
pro-inflammatory gene ...
Discovery of a novel
inhibitor of histone
lysine-specific ...
 










 
     
   Proteomics
   January 2016

Autoimmunity
January 2016

Genome Research
February 2016
 
   Secretome profiling of
   cytokines and growth factors
   reveals that neuro-glial ...

 
Histone deacetylase
inhibitors restore IL-10
expression in lipopoly
...
Metilene: fast and sensitive
calling of differentially
methylated regions from .
..
 











 
 
   Database
   January 2016

 
Genome Biol.
January 2016
Nature Communication
January 2016
 
   Ensembl regulation
   resources
Epigenomic analysis
detects aberrant super-
enhancer DNA ...
Non-CG DNA methylation
is a biomarker for
assessing endodermal...

 
 









 
     
   Dev Cell
   January 2016

Nucleic Acids Res.
January 2016
Stem Cell Int
January 2016

 
   Maternal DNA methylation
   regulates early trophoblast
   development

Ensembl 2016
Epigenetic control of
haematopoietic stem cell
aging and its clinical ...

 










 
     
   Nature Immunology
   January 2016

Biochim Biophys Acta
January 2016
Cell Reports
January 2016

 
 
   The role of the local
   environment and epigenetics
   in shaping macrophage ...

 
D-ribose-glycation of insulin
prevents amyloid aggregation
and produces cytotoxic adducts

 
Non-canonical PRC1.1 targets
active genes independent of
H3K27me3 and is ..
.