Publications

Below you will find links to the publications from the year 2014 which describe research financed by the BLUEPRINT project.
 

   Genome medicine
   December 2014

 
     
   Assessment of
   patient-derived tumour
   xenografts (PDXs) as ...


     



 
     
   Cancer Cell
   December 2014

 
Cell Reports
December 2014
Nucleic Acids Res
December 2014
 
   Epigenetic noise fuels
   cancer evolution
Genome-wide bisulfite
sequencing in zygotes
identifies demethylation ...

Inference of interactions
between chromtin modifiers
and histone modification:...
 
 










 
     
   Blood
   November 2014

 
Expert Opin Ther Pat
November 2014

 
Nucleic Acids Res
December 2014

 
 
   Cryptic XPO1-MLLT10
   translocation is associated
   with HOXA locus ...

 
Sirtuin Modulcators: an
updated patent review
(2012-2014)
NLS-tagging: an alternative
strategy to tag nuclear
proteins

 
 











 
     
   Trends Mol Med
   October 2014

 
Semin Hematol
October 2014

 
Food Chem Toxicol
November 2014

 
 
   Advances in epigenome-
   wide association studies
   for common diseases.

 
 The genomic and epi-
genomic landscapes of
AML.

 
Natural compounds in epi-
genetics: a current view.
 










 
     
   Nature Methods
   September 2014

 
Leukemia
September 2014
Eur J Med Chem
October 2014
 
   Comprehensive analysis of
   DNA methylation data with
   RnBeads.
A B-cell epigenetic signa-
ture defines three biologic
subgroups of chronic...

 
Synthesis, biological activity
and mechanistic insights of
1-substituted cyclopropyl-....
 











 
 
   Science
   September 2014

 
  Methods
  September 2014
elife
September 2014
 
   Metabolic shift may train
   immune cells

 
  Analysis pipelines and
  packages for Infinium
  HumanMethylation450 ...

High-throughput engineering
of a mammalian genome
reveals building principles...
 










 
 
   Science
   September 2014

 
  Science
  September 2014
 Science
 September 2014
 
   mTOR- and HIF-1α–mediated
   aerobic glycolysis as
   metabolic basis for trained ...


  Transcriptional diversity
  during lineage commitment
  of human blood progenitors
  Epigenetic programming of
  monocyte-to-macrophage
  differentiation and trained
..
 










 
 
   Arch Toxicol
   September 2014

 
  ACS Med Chem Lett
  September 2014

 
Nature Commun
September 2014

 
 
   Epigenetic drugs against
   cancer: an evolving
   landscape
  Novel antiproliferative
  chimeric compounds with
  marked histone ...

 
 A rare variant in APOC3
is associated with plasma
triglyceride and VLDL levels
..
 
 
 










 
     
   Genome Biol
   August 2014

 
 Oncogene
 August 2014
Nature
September 2014
 
   Methylome analysis identifies
   a Wilms tumor epigenetic
   biomarker detectable in blood

 
 The Polycombe group
 (PcG) protein EZH2
 supports the survival of .
..
 
 Dynamic and static
 maintenance of epigenetic
 memory in pluripotent and..

 
 











 
     
   Nature Methods
   August 2014

 
 Proc Natl Acad Sci USA
 August 2014

 
Methods
August 2014

 
 
   Single-cell genome-wide
   bisulfite sequencing for
   assessing epigenetic ...

 
 Short sequences can
 efficiently recruit histone
 H3 lysine 27 trimethylation...
oxBS-450K: a method for
analysing hydroxymethyl-
ation using 450K BeadChips
 












 
 
   Nucleic Acids Research
   July 2014

 
  J Medicinal Chemistry
  July 2014
Med Sci
August 2014
 
   BiQ analyzer HiMod: an
   interactive software tool
   high-throughput locus- ..
.
 
  1,3,4-Oxadiazole-containing
  histone deacetylase
  inhibitors: anticancer...

 
Functions of lncRNA in
development and disease
.
 











 
 
   Eur J Med Chem
   June 2014

 
  Epigenetics Chromatin
  June 2014
BMC Genomics
June 2014
 
   Evaluation of a large library
   of (thiazol-2-yl)hydrazones
   and analogues as histone..
.
 
  Targeted chromatin capture
  (T2C): a novel high resolution
  high throughput method ...
Relationship between genome
and epigenome - challenges
and requirements for future...
 













 
   Genome Medicine
   May 2014

 
Genome Medicine
May 2014
Cell Stem Cell
June 2014

 
 
   C2c: turning cancer into
   chronice disease.

 
 
Synergy and competition
between cancer genome
sequencing and epigenome...

Reprogramming the
methylome: erasing memory
and creating diversity
 




 






 
 










 
 
   Frontiers in Genetics
   May 2014

 
  PLoS One
  May 2014
Frontiers in Pharmacology
May 2014
 
   A symbiotic liaison between
   the genetic and epigenetic
   code.
  Properly substituted analogues
  of BIX-01294 lose inhibition of
  G9a histone methyltransferase..
Sirtuin modulators control
reactive gliosis in and in-vitro
model of Alzheimer's disease...
 






 


 
   Epigenetics
   May 2014

 
  Int J Biochem Cell Biol
  May 2014

 
Nature Genetics
May 2014

 
 
   Assessment of RainDrop
   BS-seq as a method for
   large-scale, targeted ...

 
  Identification of NuRSERY, a
  new functional HDAC complex
  composed by HDAC5, GATA1...
An atlas of genetic
influences on human
blood metabolites

 
 
 









 
     
   Cell Reports
   April 2014

 
Genome Biology
April 2014

 
Cancer Research
April 2014
 
 
   Linkage of DNA methylation
   quantitative trait loci to
   human risk

 
Evidence for the biogenesis
of more than 1,000 novel
human microRNAs


 
Context-selective death of
acute myeloid leukemia
cells triggered by the novel...

 
 










 
     
   Curr Opin Genet Dev
   April 2014
 
    
Genes Chromos Cancer
April 2014

 
 Bioinformatics
 April 2014

 
 
   Genomic patterns and context
   specific interpretation of DNA
   methylation

 
Recurrent mutation if JAK3
in T-cell prolymphocytic
leukemia

 
 WiggleTools: parallel
 processing of large
 collections of genome-wide...
 
 








 












 
   Antioxid Redox Signal
   March 2014

 
J Clin Invest
April 2014
J Mol Cell Biol
April 2014
 
   Targeting histone deacety-
   lases in diseases:
   where are we?

 
 HBS1L-MYB intergenic
 variants modulate fetal
 hemoglobin via longe-range...
Reversible acytelation
regulates vascular endo-
thelial growth factor-2 activity.
 











 
 
   Genome Medicine
   March 2014

 
Genome Medicine
March 2014

 
Genome Medicine
March 2014

 
 
   Correcting for cell-type
   composition bias in
   epigenome-wide ...

 
Human-specific epigenetic
variation in the immunological
leukotriene B4 receptor ...

Interrogating causal pathways
linking genetic variants, small
molecule metabolites, and ...
 






   
   PLoS Biology
   February 2014

 
ChemMedChem
March 2014
Future Oncology
March 2014
 
   Pre-B cell receptor
   signalling induces immuno
   globin K locus accessibility...

 
Quinoline-based p300
histone acetyltransferase
inhibitors with apoptotic...
Next generation sequencing
and DNA replication in human
cells: the future has ...
 
 










 
   
   Nature Methods
   February 2014

 
PLoS Genetics
February 2014
J Medicinal Chemistry
February 2014
 
   Functional annotation of
   noncoding sequencing
   variants
.
 
DNA sequence explains
seemingly disordered
methylation levels in ...
Selective non-nucleoside
inhibitors of human DNA
methyltransferase active...
 










 
 

 
   
   BMC Cancer
   February 2014

 
 Bioinformatics
 February 2014

 
Epigenomics
February 2014

 
 
   Pharmacological inhibition
   of EZH2 as a promosing
   differentiation therapy in ..

 
 ChAMP: 450k Chip analysis
 methylation pipeline
Human-specific CpG
'beacons' identify human-
specific prefrontal cortex ...
 












 
   
   Bioessays
   February 2014

 
Genome Biology
February 2014
Nature Commun
February 2014
 
   Funtional interpretation
   of non-coding sequence
   variation: concepts and ...

Using high-density DNA
methylation arrays to
profile copy number .
..
Differential methylation of
the TRPA1 promoter in pain
sensitivity.

 
 











 



 
 
   Nucleic Acids Res
   January 2014

 
J Hematol Oncol
January 2014
J Med Chem
January 2014

 
 
   Ensembl 2014

Hypermethylation of the
alternative AWT1 promoter
in hematological malignancies..

 
Pan-histone demethylase
inhibitors simultanuously
targeting Jumonji C and ...