Publications

Below you will find links to the publications from the year 2015 which describe research financed by the BLUEPRINT project.

 

   Bioinformatics
   December 2015

Nature 
December 2015
   
   An interactive genome browser
   of association results from the
   UK10K cohorts project
Competetion between DNA
methylation and transcription
factors determines binding...

 
   
   










 
     
   Genome Medicine
   November 2015

Cell
November 2015 
BMC Syst Biol
Novermber 2015
 
   A donor-specific epigenetic
   classifier for acute graft-
   versus-host disease ...
Transcriptional heterogeneity
and lineage commitment in
myeloid progenitors
 
Reconstruction of gene
networks using prior
knowledge 
 
   





 
 










 
   
   Stem Cell Reports
   November 2015
 
Eur J Med Chem
November 2015
Cell Reports
December 2015
 
   Glioblastoma stem cells
   respond to differetiation cues
   but fail to undergo ...

Enzyme kinetics and
inhibition of histone
acetyltransferase KAT8
Differential DNA methylation
analysis without a
reference genome
 
     
       

 

 
   
   Oncogene
   October 2015

Cell Reports
October 2015
Int J Biochem Cell Biol
October 2015

 
 
   DNMT3A mutations mediate
   the epigenetic reactivation of
   the leukemogenic factor...

Cell cycle-dependent
reconfiguration of the DNA
(hydroxy)methylome ...
Epigenetic-based therapy:
from single- to multi-
target approaches

 
 











 
     
   Proc. Natl. Acad. Sci. USA
   September 2015

Nucleic Acids Res
September 2015
Nature Genetics
October 2015
 
   MINCR is a MYC-induced
   lncRNA able to modulate
   MYC's transcriptional ...
The interplay between DNA
methylation and sequence
divergence in recent ...

DNA methylation analysis
in Burkitt and follicular
lymphomas identifies ...
 










 
     
   ACS Chem Biol
   September 2015

Nature Commun
September 2015 
Genome Biology
September 2015 
 
   Discovery of inhibitors for
   the Ether Lipid generating
   enzyme AGPS as ...
Improved imputation of
low-frequency and rare
variants using the UK10K... 
The senescent methylome
and its relationship with
cancer, ageing, and ...
 
 



 







 
     
   Arterioscler Thromb Vasc
   August 2015

Nature Methods
August 2015

Curr Top Med Chem
August 2015
 
   DNA methylation dynamics
   in human carotid plaques
   after cerebrovascular ...
ChIPmentation: fast,
robust, low-input ChIP-seq
for histones and ...
DNA methyltransferases
inhibitors from natural
resources

 



 
   









 
 
   Nature
   July 2015

Genome Biology
July 2015
Hypertension
July 2015
 
   Non-coding recurrent
   mutations in chronic
   lymphocytic leukemia.
Chromatin segmentation
based on a probabilistic
model for read counts...
Metabolomic identification
of a novel pathway of
blood pressure regulation...

 










 
     
   Methods Mol Biol
   July 2015

 
Clinic Cancer Res
July 2015
Genome Biology
July 2015

 
 
   Nano-MeDIP-seq
   methylome analysis using
   low DNA concentrations.
Prognostic impact of novel
molecular subtypes of
small intestinal neuro.....
Epigenome data release:
a participant-centered
approach to privacy....

 











 
 









 
   
   Nature Genetics
   July 2015
Genome Medicine
July 2015

 
Oncogene
July 2015
 
   Whole-genome fingerprint
   of the DNA methylome
   during human B cell ...
Brave new epigenomes:
the dawn of epigenetic
engineering

 
The oncofusion protein
FUS-ERG targets key
hematopoietic regulators..
 











 
     
   Endocr Relat Cancer
   June 2015

 
Expert Opin Drug Discov
June 2015
J Mol Cell Cardiol
June 2015
 
   Epigenetic dysregulation
   and poorer prognosis in
   DAXX-deficient ...

 
Emerging approaches for
histone deacetylase
inhibitor drug discovery.

 
Sirtuin function in ageing
heart and vessels.

 
 
 









 
     
   BMC Genomics
   April 2015

 
J Med Chem
May 2015
Expert Opin Ther Targets
May 2015
 
   Sexually dimorphic
    gene expression
    emerges with ...
Novel histone deacetylase
inhibitors induce growth
arrest, apoptosis, and ...
Genetic mutations in
epigenetics modifiers as
therapeutic targets in ...

 
 










 
 
   J Immunol
   April 2015

 
Nature
April 2015
Nature Communications
April 2015

 
 
   Transcription-dependent
   generation of a specialized
   chromatin structure at...

 
Genomic profiling of DNA
methyltransferases reveals
a role for DNMT3B in ....
High-throughput and
quantitative assessment of
enhancer activity in ...
 










 
   Genome Biol
   March 2015

 
Genome Research
March 2015
Eur J Med Chem
April 2015
 
   The ensembl regulatory
   build
Whole-epigenome analysis
in multiple myeloma reveals
DNA hypermethylation...

 
Pure enantiomers of
benzoylamino-tranyl-
cypromine: LSD1...
 
 




 
 









 
   
   Med Sci (Paris)
   March 2015

Clin Cancer Res
March 2015

 
J Biol Chem
March 2015

 
 
   The European BLUEPRINT
   project: towards a full
   epigenome characterization...

Epigenetic markers of
metastasis and HPV-
induced tumorigenesis...

 
New insights on the 
mechanism of quinoline-
based DNA methyl...
.
 
 










 
 
   BMC Med Genomics
   February 2015

 
 Cell Reports
 February 2015
Leukemia
March 2015

 
   The DNA methylation
   drift of atherosclerotic
   aorta increases ...

 
 Single-cell DNA
 methylome sequencing
 and bioinformatic...
A B-cell epigenetic
signature defines three
biologic subgroups of ...
 
 





 
 









 
   
   Autophagy
   February 2015
Genome Medicine
February 2015
ACS Med Chem Lett
February 2015

 
 
   SIRT5 regulation of
   ammonia-induced
   autophagy and mitophagy

 
Comparative methylome
analysis identifies new
tumour subtypes and ...
Pure diastereomeres of a
Tranylcypromine-based
LSD1-inhibitor: enzyme ...
 
     










 
 
   Genome Medicine
   January 2015

 
 Nature Communications
 January 2015

 
Cell Reports
February 2015

 
 
   Higher gene expression
   variability in the more
   aggressive subtype of...

 
 Low-frequency and rare exome
 chip variants associate with 

 fasting glucose and type ...
 
Epigenome mapping reveals
distinct modes of gene
regulation and widespread ...

 
     










 
 
   Nucleic Acids Res
   January 2015

 
Nucleic Acids Res
January 2015

 
ChemMedChem
January 2015

 
 
   Ensembl 2015
 
ChiTaRS 2.1 - an improved
database of the chimeric
transcripts and RNA-seq ...

 
Identification of structural
features of 2-alkylidene-1,3-
dicarbonyl derivatives...
 











 
   
   Methods
   January 2015

 
Epigenetics
January 2015
Oncotarget
January 2015
 
   Probe Lasso: a novel
   method to rope in
   differentially methylated...
ARHGEF3 controls HDACi-
induced differentiation via
RhoA-dependent...

 
HDAC2 deregulation in
tumorigenesis is causally
connected to repression of...